Platelet-Rich Fibrin (PRF) is an autologous biomaterial that is increasingly used in regenerative dentistry due to its enrichment with growth factors and cytokines, which aid in tissue healing and regeneration. Its advantages over previous platelet concentrates, such as PRP, include its solid form, easier handling, and sustained release of bioactive molecules. Low-Level Laser Therapy (LLLT), which has biomodulatory effects, is also widely used in dentistry to enhance healing and reduce inflammation. While both PRF and LLLT have been separately explored for their regenerative effects, limited research has investigated their combined use across various dental specialties. This study aims to review the synergistic effects of PRF and LLLT, focusing on their potential for improving clinical outcomes in areas like bone regeneration, gingival depigmentation, and pulp capping. A review of experimental studies conducted between 2023 and February 2025 was carried out, using the PICO framework to ensure methodological precision. The results suggest that combining PRF and LLLT may lead to enhanced regenerative outcomes, such as improved bone formation, better sensory neural recovery, and more effective soft tissue healing compared to the use of each treatment alone. Despite promising findings, some studies showed inconsistencies, emphasizing the need for further research to better understand the combined effects and optimize treatment protocols. The study concludes that combining PRF and LLLT holds potential for improving clinical outcomes in various dental treatments, but more well-controlled trials are needed to confirm their synergistic efficacy and establish standardized guidelines for their application.
Platelet-Rich Fibrin (PRF) is an autologous biomaterial that is increasingly used in regenerative dentistry due to its enrichment with growth factors and cytokines, which aid in tissue healing and regeneration. Its advantages over previous platelet concentrates, such as PRP, include its solid form, easier handling, and sustained release of bioactive molecules. Low-Level Laser Therapy (LLLT), which has biomodulatory effects, is also widely used in dentistry to enhance healing and reduce inflammation. While both PRF and LLLT have been separately explored for their regenerative effects, limited research has investigated their combined use across various dental specialties. This study aims to review the synergistic effects of PRF and LLLT, focusing on their potential for improving clinical outcomes in areas like bone regeneration, gingival depigmentation, and pulp capping. A review of experimental studies conducted between 2023 and February 2025 was carried out, using the PICO framework to ensure methodological precision. The results suggest that combining PRF and LLLT may lead to enhanced regenerative outcomes, such as improved bone formation, better sensory neural recovery, and more effective soft tissue healing compared to the use of each treatment alone. Despite promising findings, some studies showed inconsistencies, emphasizing the need for further research to better understand the combined effects and optimize treatment protocols. The study concludes that combining PRF and LLLT holds potential for improving clinical outcomes in various dental treatments, but more well-controlled trials are needed to confirm their synergistic efficacy and establish standardized guidelines for their application.
نوع مطالعه:
Review article |
موضوع مقاله:
Surgery دریافت: 1403/11/30 | پذیرش: 1403/8/30 | انتشار: 1403/7/10