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Volume 13, Issue 1 (4-2024)
2024, 13(1): 48-48 |
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Alzain F, Roholamin M, Jafari E, Hesari Z. Formulation and Physicochemical Control of Local Anti-hemorrhage Solution of Aluminum Chloride for Oral and Dental Surgeries. Journal title 2024; 13 (1) :48-48
URL: http://3dj.gums.ac.ir/article-1-606-en.html
URL: http://3dj.gums.ac.ir/article-1-606-en.html
1- Department of Pharmaceutics, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
2- Biotechnology student at Amol University of Special Modern Technologies, Amol, Iran
3- Department of Dental Prostheses, Faculty of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Department of Pharmaceutics, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran ,z.hesari@gmail.com
2- Biotechnology student at Amol University of Special Modern Technologies, Amol, Iran
3- Department of Dental Prostheses, Faculty of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Department of Pharmaceutics, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran ,
Abstract: (507 Views)
Introduction: During oral surgery, bleeding is one of the expected side effects, specifically in the critical areas such as head and neck. Accordingly, developing optimal homeostatic agents is of concern in this study in order to produce more efficiently optimal homeostasis both in terms of cost and performance.
Materials and Methods: To make a 25% aluminum chloride solution, aluminum chloride (hexa-hydrate) powder, propylene glycol, ethanol or distilled water were used, sodium bicarbonate solution with different concentrations was utilized to adjust the pH of the solution, after that, physicochemical evaluations were performed including appearance (transparency), viscosity and drug content by complexometric titration.
Results: Two final formulations (B12 and B13) with acceptable pH, viscosity and drug content i.e., pH: 2.29 and 2.5 with respective viscosities: 7.55 and 5.12 cp as well as drug content of 100 % for both of them were selected.
Conclusion: The outcome revealed that formulations (B12 and B13) of 25% aluminum chloride, propylene glycol (6 &8 mL, respectively) and 1 M sodium carbonate was made, which had an acceptable pH and viscosity while maintaining its therapeutic properties.
Materials and Methods: To make a 25% aluminum chloride solution, aluminum chloride (hexa-hydrate) powder, propylene glycol, ethanol or distilled water were used, sodium bicarbonate solution with different concentrations was utilized to adjust the pH of the solution, after that, physicochemical evaluations were performed including appearance (transparency), viscosity and drug content by complexometric titration.
Results: Two final formulations (B12 and B13) with acceptable pH, viscosity and drug content i.e., pH: 2.29 and 2.5 with respective viscosities: 7.55 and 5.12 cp as well as drug content of 100 % for both of them were selected.
Conclusion: The outcome revealed that formulations (B12 and B13) of 25% aluminum chloride, propylene glycol (6 &8 mL, respectively) and 1 M sodium carbonate was made, which had an acceptable pH and viscosity while maintaining its therapeutic properties.
Keywords: Aluminum chloride, Blood coagulant, Oral/Dental surgeries, Hydrogen-lon Concentration, viscosity
Type of Study: Original article |
Subject:
So on
Received: 2024/05/25 | Accepted: 2024/07/31 | Published: 2024/04/22
Received: 2024/05/25 | Accepted: 2024/07/31 | Published: 2024/04/22
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Owned by Guilan University of Medical Sciences.
Co-published by Zamen Salamati.
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The end of professor Samii Blv, Guilan University of Medical Sciences Complex, Dental School, Rasht, Iran.
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Publisher Tel : +9821 86037228 , 86036497
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