Introdouction: Squamous cell carcinoma is the most common oral cancer and the prognosis because of a late diagnosis remains poor despite numerous treatments. Therefore, we conducted a cross-sectional study to investigate the relationships between survival rate(SR) of oral squamous cell carcinoma (OSCC) and clinical,demographic, pathological, and molecular factors in Yazd city during 1998– 2008.

Materials and methods: Data related to 30 Yazdian patients with OSCC who were referred to Shahid Sadoughi Dental School and Hospital during 1998–2008 were evaluated according to census data. Clinical and histopathological data were gathered via phone calls, and archived specimens were immunohistochemically stained to examine the cell proliferation index (Ki-67), the anti-apoptotic index (bcl2), and a tumor suppressor indicator(p53). The data were analyzed using SPSS statistical software (V.17) via a Kaplan–Meier analysis, and p <0.05 was considered significant.
Results: Eighteen cases (60%) were females and 12(40%) were males. The mean 5-year SR was lower in men than women and in patients >50 years of age than <50 years, the mean SR from lowest to highest were record to labial, lingual and intraoral involvement respectively and for smokers and patients with a moderate disease grade(II) and intense p53 staining tended to be lower than other categories however, the differences were not significant. The overall 5-year SR of patients was 55% in this study, and the mean survival was 6.6 years.
Conclusion: The SR was lower in older men and smokers Therefore, a more radical treatment and longer follow-upafter treatment for older male smokers are recommended.