Introduction: Central giant cell granuloma is a benign lesion but sometimes has aggressive proliferation composed of multinucleated giant cells in a background of spindle and ovoid mesenchymal cells. Multifocal central giant cell granuloma of jaws is very rare and usually associated with hyperparathyroidism and some syndromes. We described an un-usual case of a 22-year-old man with idi-opathic multiple central giant cell granuloma of mandible without significant clinical find-ings. The parathyroid hormone level, calcium and phosphorus inorganic were in normal limit. Patient had no familial history and clinical characteristic of Cherubism, Noonan-like syndrome and neurofibromatosis. This article refers to the fact that multiple central giant cell granuloma may be associated with no signs of systemic or specific syndromes and it can be an independent and idiopathic disease.