Introduction:
Kikuchi-Fujimoto disease or histocytic necrotizing lymphadenitis is a rare, benign, self-limited condition characterized by constitutional symptoms, lymphadenopathy, and skin lesions and often affects young adult females.The etiology is unknown although viruses and autoimmune mechanisms has been suggested. Diagnosis is fundamentally based on the affected lymph node biopsy.The patient was a 34 years old female,refered without any history of fever, rash,loss of weight associated with right cervical submandibular lymphadenopathy and earache. Laboratory data were normal other than a little increase of ESR, CRP.Finally Cervical lymph node excisional biopsy was performed and Necrotising Lymphadenitis was diagnosed.Then she was treated with steroids and lymph nodes were shorten within 1 month but recured.Finally with possible diagnosis of Human Herpes Virus and after prescription of Acyclovir patient`s lymphadenopathy absolutely resolved and it didnt recur within 6 months.