Volume 6, Issue 3 (Autumn 2017 2017)                   3dj 2017, 6(3): 61-68 | Back to browse issues page


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1- DDS, Dentist, Department of Oral Medicine, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
2- DDS, Dentist, Department of Oral Medicine, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
3- MSc., Oral and Dental Diseases Center, Kerman University of Medical Sciences, Kerman, Iran.
Abstract:   (135 Views)
Introduction: Several studies have been conducted to examine the effect of suture material on the skin during healing of the wound while a few articles reviewed the musculoskeletal response. In this study, the effects of the two plants, myrtle and fenugreek, on the primary inflammatory response of the tongue muscles to the types of suture in diabetic rats are examined.
Materials and Methods: For conducting this study, 96 Wistar healthy male white rats weighing between 250 and 300 g were selected. The animals were divided into 3 groups, 32 each, consisting of the diabetic group, the diabetic-myrtle group, and the diabetic-fenugreek group. All the animals became diabetic two weeks before the study using Streptozotocin (STZ). For carrying out the task, all animals were anesthetized on the first day using ketamine with a dosage of 60 mg/kg and xylazine (Rampon) with a dosage of 5.7 mg/kg. Four wounds were made using No. 15 blade, and each wound was sutured using one sample of suture string (simple interrupted suture). Then, in the myrtle and fenugreek groups, these materials were placed on the sutures using swabs. After this, from each group, 8 animals were sacrificed using ether. On days 2, 4, 7 and 14, samples were taken from the suture sites with intact margins and were sent to the pathological lab, and the degree of inflammation was examined using a light microscope with magnifications of 40 and 100. At last, the data were analyzed using Wilcoxon, post hoc ( by SPSS version 13.5).
Results: This study showed that the least amount of inflammation on all days was associated with silk string followed by plain catgut in the diabetic group, and there was a significant relationship (P=0.001) in that regard with the two other suture strings used; chromic catgut and monofilament polyamide. In the myrtle group, chromic catgut and monofilament polyamide inflammation were not significantly different as compared with the other two suture strings in the control group on all days of the study. The findings showed that in the fenugreek group and the control silk and monofilament polyamide, the inflammation severity was not significantly different from the two suture strings in the control group on all days of the study.
Conclusion: The findings of this study showed that the two plants myrtle and fenugreek reduce the inflammatory response in plain catgut though the effect of myrtle was more significant. Myrtle is also effective in reducing inflammation in silk while fenugreek is effective in reducing the inflammation caused by chromic catgut.
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Type of Study: Original article | Subject: So on
Received: 2017/03/16 | Accepted: 2017/07/10 | Published: 2017/10/1

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