Volume 4, Issue 2 (9-2015)                   2015, 4(2): 30-34 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Atarbashi Moghadam S, Mohsenifar Z, Lotfi A, Abasi L, Bagheri S S. Fascin Expression in Oral Squamous Cell Carcinoma using an Immunohistochemical Technique. Journal title 2015; 4 (2) :30-34
URL: http://3dj.gums.ac.ir/article-1-170-en.html
1- Department of Oral and Maxillofacial Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Pathology, Taleghani Eِducational Hospital of Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Tehran, Iran
4- Department of Oral and Maxillofacial Pathology, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (4007 Views)

Introdouction: Oral squamous cell carcinoma (OSCC), the most common form of oral cancer, requires early diagnosis and suitable treatments. Fascin is a protein involved in cell adhesion and is increased in expression in certain types of carcinomas. The present study was conducted to assess fascin expression in OSCC using an immunohistochemical technique.
Materials and methods: In the present retrospective study, 25 paraffin blocks of OSCC samples were selected and immunohistochemically stained for detection of fascin expression. Fascin expression rate was calculated as the sum of stained cells (scores from 0 to 4) and staining intensity (scores from 0 to 3).
Results: Samples collected from 18 men and 7 women, with a mean age of 57.42 years, were assessed, which showed that the most usually affected sites were the gingiva and the tongue. Fascin expression was positive for all the samples and had the highest possible score (24 cases with score 7 and 1 case with score 6). Fascin expression level was not found to have a significant relationship with age, gender, and tumor location (P > 0.05). The data were analyzed using SPSS statistical software (18) via chi-square analysis, independent T test and One way Anova p <0.05 was considered significant.
Conclusion: Irrespective of the clinical parameters, fascin expression is possibly involved in the etiology of OSCC target therapy medicines can therefore be used in the future to treat this malignancy.

Full-Text [PDF 556 kb]   (1206 Downloads)    
Type of Study: Original article | Subject: Pathology
Received: 2015/09/13 | Accepted: 2015/09/13 | Published: 2015/09/13

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Dentomaxillofacial

Designed & Developed by : Yektaweb