Volume 7, Issue 1 (Spring 2018)                   3dj 2018, 7(1): 37-42 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Aminishakib P, Kashefi M, Moradi Ghahdarijani B, Yazdani F, Nafarzadeh S, Gholami A, et al . Neoangiogenesis in Benign and Malignant Salivary Gland Tumors. 3dj. 2018; 7 (1) :37-42
URL: http://3dj.gums.ac.ir/article-1-299-en.html
1- Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
2- Dental Material Research Center, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
3- School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
4- Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
5- Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
6- Social Determinant of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
7- Department of Oral and Maxillofacial Pathology, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran. , dr.mehrabi@zums.ac.ir
Abstract:   (143 Views)
Introduction: There are few studies investigating the role of neoangiogenesis in biological behavior of salivary gland tumors. CD105 expression has demonstrated greater accuracy for detecting new vessel formation compared with other pan-endothelial molecules. This study aimed to assess and compare intratumoral Micro-Vessel Density (MVD) through using immunohistochemichal expression of CD105 biomarker in Mucoepidermoid Carcinoma (MEC), Adenoid Cystic Carcinoma (AdCC) and Pleomorphic Adenoma (PA).
Materials and Methods: CD105 expression using Immunohistochemistry (IHC) was assessed in 20 cases of PA, 20 cases of AdCC, 20 cases of MEC, and 10 cases of normal salivary gland tissues. Positive intratumoral micro-vessels for CD105 expression were measured quantitatively for the assessment of Micro-Vessel Density (MVD) in each group. Groups differences in MVD was analyzed statistically using the Mann-Whitney U test and Kruskal-Wallis test. One-way ANOVA and post hoc Tukey test were also carried out. P values less than 0.05 were considered statistically significant.
Results: CD105 positive vessels were rarely seen in normal salivary gland tissue. Statistically significant differences in MVD were observed between the normal salivary gland tissue and AdCC and also MEC (P<0.017 and P<0.001, respectively). There was a statistically significant difference in MVD between PA and AdCC and also MEC (P<0.018 and P<0.001, respectively). MVD was higher in MEC in comparison with AdCC (P<0.002).
Conclusion: The results of the current study demonstrated higher neoangiogenesis in AdCC and MEC by measuring CD105 expression, which suggests a possible role for this phenomenon in aggressive behavior of these malignant salivary gland tumors.
Full-Text [PDF 780 kb]   (28 Downloads) |   |   Full-Text (HTML)  (22 Views)  
Type of Study: Original article | Subject: Pathology
Received: 2017/09/28 | Accepted: 2018/01/10 | Published: 2018/03/1

References
1. Cardoso SV, Souza KC, Faria PR, Eisenberg AL, Dias FL, Loyola AM. Assessment of angiogenesis by CD105 antigen in epithelial salivary gland neoplasms with diverse metastatic behavior. BMC Cancer. 2009; 9:391. [DOI:10.1186/1471-2407-9-391] [PMID] [PMCID] [DOI:10.1186/1471-2407-9-391]
2. Gleber Netto FO, Florencio TN, de Sousa SF, Abreu MH, Mendonca EF, Aguiar MC. Angiogenesis and lymphangiogenesis in mucoepidermoid carcinoma of minor salivary glands. Journal of Oral Pathology & Medicine . 2010; 41(8):603-9. [DOI:10.1111/j.1600-0714.2012.01153.x] [PMID] [DOI:10.1111/j.1600-0714.2012.01153.x]
3. Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. Philadelphia: Saunders; 2015.
4. Hillen F, Griffioen AW. Tumour vascularization: sprouting angiogenesis and beyond. Cancer and Metastasis Reviews. 2007; 26(3-4):489-502. [DOI:10.1007/s10555-007-9094-7] [PMID] [PMCID] [DOI:10.1007/s10555-007-9094-7]
5. Marioni G, Alessandro ED, Giacomelli L, Staffieri A. CD105 is a marker of tumour vasculature and a potential target for the treatment of head and neck squamous cell carcinoma. Journal of Oral Pathology & Medicine. 2010; 39(5):361-7. [DOI:10.1111/j.1600-0714.2010.00888.x] [PMID] [DOI:10.1111/j.1600-0714.2010.00888.x]
6. Alaeddini M, Salah S, Dehghan F, Eshghyar N, Etemad Moghadam S. Comparison of angiogenesis in keratocystic odontogenic tumours, dentigerous cysts and ameloblastomas. Oral Diseases. 2009; 15(6):422-7. [DOI:10.1111/j.1601-0825.2009.01566.x] [PMID] [DOI:10.1111/j.1601-0825.2009.01566.x]
7. Kumagai Y, Sobajima J, Higashi M, Ishiguro T, Fukuchi M, Ishibashi K. Angiogenesis in superficial esophageal squamous cell carcinoma: Assessment of micro vessel density based on immunostaining for CD34 and CD105. Japanese Journal of Clinical Oncology. 2014; 44(6):526-33. [DOI:10.1093/jjco/hyu039] [PMID] [DOI:10.1093/jjco/hyu039]
8. Basnaker M, Sr S, Bnvs S. Expression of endoglin (CD105) and microvessel density in oral dysplasia and squamous cell carcinoma. Journal of Clinical and Diagnostic Research for doctors. 2014; 8(9):ZC91-4. [DOI:10.7860/JCDR/2014/9429.4904 ] [PMID] [PMCID] [DOI:10.7860/JCDR/2014/9429.4904]
9. Tae K, El Naggar AK, Yoo E, Feng L, Lee JJ, Hong WK, et al. Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis. Clinical Cancer Research. 2000; 6(7):2821-8. [PMID] [PMID]
10. Duff SE, Li C, Garland JM, Kumar S. CD105 is important for angiogenesis: Evidence and potential applications. The FASEB Journal. 2003; 17(9):984-92. [DOI:10.1096/fj.02-0634rev] [PMID] [DOI:10.1096/fj.02-0634rev]
11. Goumans MJ, Lebrin F, Valdimarsdottir G. Controlling the angiogenic switch: A balance between two distinct TGF-b receptor signaling pathways. Trends in Cardiovascular Medicine. 2003; 13(7):301-7. [DOI:10.1016/S1050-1738(03)00142-7] [DOI:10.1016/S1050-1738(03)00142-7]
12. Fonsatti E, Altomonte M, Nicotra MR, Natali PG, Maio M. Endoglin (CD105): A powerful therapeutic target on tumor-associated angiogenetic blood vessels. Oncogene. 2003; 22(42):6557-63. [DOI:10.1038/sj.onc.1206813] [PMID] [DOI:10.1038/sj.onc.1206813]
13. Eshghyar N, Mohammadi N, Rahrotaban S, Motahhary P, Vahedi Vaez SM. Endoglin (CD105) positive microvessel density and its relationship with lymph node metastasis in squamous cell carcinoma of the tongue. Archives of Iranian Medicine. 2011; 14(4):276-80. [PMID] [PMID]
14. Vermeulen PB, Gasparini G, Fox SB, Colpaert C, Marson LP, Gion M, et al. Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours. European Journal of Cancer . 2002; 38(12):1564-79. [DOI:10.1016/S0959-8049(02)00094-1] [DOI:10.1016/S0959-8049(02)00094-1]
15. Singh S, Sadanandam A, Singh RK. Chemokines in tumor angiogenesis and metastasis. Cancer and Metastasis Reviews. 2007; 26(3-4):453-67. [DOI:10.1007/s10555-007-9068-9] [PMID] [PMCID] [DOI:10.1007/s10555-007-9068-9]
16. Lakshman M, Huang X, Ananthanarayanan V, Jovanovic B, Liu Y, Craft CS, et al. Endglin suppresses human prostate cancer metastasis. Clinical & Experimental Metastasis. 2011; 28(1):39-53. [DOI:10.1007/s10585-010-9356-6] [PMID] [PMCID] [DOI:10.1007/s10585-010-9356-6]
17. Martone T, Rosso P, Albera R, Migliaretti G, Fraire F, Pignataro L, et al. Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome. Oral Oncology. 2005; 41(2):147-55. [DOI:10.1016/j.oraloncology.2004.08.001] [PMID] [DOI:10.1016/j.oraloncology.2004.08.001]
18. Schimming R, Marmé D. Endoglin (CD105) expression in squamous cell carcinoma of the oral cavity. Head & Neck. 2002; 24(2):151-6. [DOI:10.1002/hed.10040] [PMID] [DOI:10.1002/hed.10040]
19. Chien CY, Su CY, Hwang CF, Chuang HC, Hsiao YC, Wu SL, et al. Clinicopathologic signicance of CD105 expression in squamous cell carcinoma of the hypopharynx. Head & Neck. 2006; 28(5):441-6. [DOI:10.1002/hed.20364] [PMID] [DOI:10.1002/hed.20364]
20. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000; 407(6801):249-57. [DOI:10.1038/35025220] [PMID] [DOI:10.1038/35025220]
21. Du JR, Jiang Y, Zhang YM, Fu H. Vascular endothelial growth factor and microvascular density in esophageal and gastric carcinomas. World Journal of Gastroenterology. 2003; 9(7):1604-6. [DOI:10.3748/wjg.v9.i7.1604] [PMID] [PMCID] [DOI:10.3748/wjg.v9.i7.1604]
22. Sharma S, Sharma MC, Sarkar C. Morphology of angiogenesis in human cancer: A conceptual overview, histoprognostic perspective and significance of neoangiogenesis. Histopathology. 2005; 46(5):481-9. [DOI:10.1111/j.1365-2559.2005.02142.x] [PMID] [DOI:10.1111/j.1365-2559.2005.02142.x]
23. Cwiklnska A, Sobstyl M, Kwasniewski W, Bednarek W. Microtissue density prognostic factor evaluation based on antigens CD34 and CD 105 in ovarian cancer patients. Annals of Agricultural and Environmental Medicine. 2013; 20(4):838-42. [PMID] [PMID]
24. Costa AF, Demasi AP, Bonfitto VL, Bonfitto JF, Furuse C, Araujo VC. Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. Virchows Archiv. 2008; 453(4):359-67. [DOI:10.1007/s00428-008-0664-z] [PMID] [DOI:10.1007/s00428-008-0664-z]
25. Barsky SH, Karlin NJ. Myoepithelial cells: Autocrine and paracrine suppressors of breast cancer progression. Journal of Mammary Gland Biology and Neoplasia. 2005; 10(3):249-60. [DOI:10.1007/s10911-005-9585-5] [PMID] [DOI:10.1007/s10911-005-9585-5]
26. Nguyen M, Lee MC, Wang JL, Tomlinson JS, Shao ZM, Alpaugh ML. The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. Oncogene. 2000; 19(31):3449-59. [DOI:10.1038/sj.onc.1203677] [PMID] [DOI:10.1038/sj.onc.1203677]
27. Gadbail AR, Hande A, Chaudhary M, Nikam A, Gawande M, Patil S, et al. Tumor angiogenesis in keratocystic odontogenic tumor assessed by using CD-105 antigen. Journal of Oral Pathology & Medicine. 2011; 40(3):263-9. [DOI:10.1111/j.1600-0714.2010.00962.x] [PMID] [DOI:10.1111/j.1600-0714.2010.00962.x]
28. Paez Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009; 15(3):220-31. [DOI:10.1016/j.ccr.2009.01.027] [PMID] [PMCID] [DOI:10.1016/j.ccr.2009.01.027]

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2019 All Rights Reserved | Journal of Dentomaxillofacial

Designed & Developed by : Yektaweb